The name Trismegistus means "Thrice-Great" — a title drawn from Egyptian traditions about Thoth, who was called "the great, the great, the great" in hieroglyphic inscriptions. The fusion of Hermes and Thoth was natural: both were gods of wisdom and writing, both were psychopomps (guides of souls), both were associated with magic and secret knowledge. In the cosmopolitan intellectual climate of Hellenistic Alexandria, the two merged into a single mythological sage who had received — or embodied — the complete wisdom of both traditions.
The Renaissance transformed Hermes Trismegistus from a Hellenistic literary device into a historical sage of the highest authority. When Cosimo de' Medici in 1463 ordered his scholar Marsilio Ficino to translate the newly discovered Greek manuscripts of the Corpus Hermeticum before completing his translation of Plato, it was because the Hermetic texts were believed to predate Plato — to represent the prisca theologia (ancient theology), the original revelation given by God to humanity at the dawn of civilisation. Hermes Trismegistus was placed alongside Moses and Zoroaster as one of the great prophets of the ancient world.
This belief was demolished in 1614 by the Swiss scholar Isaac Casaubon, who demonstrated through detailed philological analysis that the Corpus Hermeticum was written in the early centuries of the Common Era — not thousands of years before. The Renaissance Hermetic tradition was built on a chronological error. Yet the demolition of the historical claim did not destroy the tradition's vitality — the ideas continued to circulate, influence and generate new syntheses regardless of the date of their composition.