MKUltra was the CIA's systematic attempt to develop reliable methods of mind control — techniques that could produce confession, amnesia, altered personality, and absolute compliance in human subjects. The programme grew directly from post-WWII intelligence gathering on Nazi and Soviet mind control research, and from the CIA's Cold War fear that the Soviets had developed a "brainwashing" capability that the US needed to match or exceed.
The programme operated through over 150 subprojects conducted at universities, hospitals, prisons, and CIA safe houses across the United States and Canada. Many subjects — prisoners, mental patients, CIA employees, military personnel, and ordinary citizens — were experimented on without their knowledge or consent. Some died. Many suffered permanent psychological damage. None were told what had been done to them.
The director of MKUltra's technical operations was Sidney Gottlieb — a CIA chemist and poison expert who became the programme's chief architect. Gottlieb personally ordered the destruction of MKUltra files in 1973, two years before the programme was revealed to Congress. He died in 1999, having never faced criminal charges. His biography, published posthumously, is titled Poisoner in Chief.